u/Zorcron

Not the person you asked, but I bought this one a little over a year ago and it’s been great; similar to what clantontann described. https://a.co/d/02O7sQ3S

I mean “slow” is essentially the original meaning in English. “Mentally retarded” means basically the same thing as a newer term “developmentally delayed”. Same as something being fire retardant, just means it slows fire down.

Anyone experiencing unwanted weight loss should obviously talk to their doctor, but there are options like reducing dose (The most potent weight loss drug we have now is tirzepatide, and it comes in 6 strengths from 2.5mg to 15mg), switching to a different, less potent variety, or coming off the drug if the weight loss effects are no longer needed.

People have been taking GLP-1 agonists for 20 years. Exenatide was approved in 2005. The newer drugs are more potent, but largely have the same side effects as the older drugs, and work on the same or similar targets in the body. We will continue to study the long term efficacy and safety of these newer drugs, but people are dying of diabetes and heart disease now, and these drugs can help.

For many people, the currently known side effects and the chance that we discover some new long-term side effect are outweighed by the risks of their current diseases that these drugs treat or prevent.

Exenatide (Byetta, Bydureon) was approved for diabetes by the FDA in 2005, and liraglutide (Victoza, Saxenda) was approved for diabetes in 2010 and weight loss in 2015. The newer drugs are more potent, but their side effect profiles seem similar to the older drugs, of which there are plenty of long-term safety studies of.

Of course there is ongoing research into long-term safety of every newly approved drug, but there’s no reason to believe they will be any less safe than the previous drugs. With our current data, the benefits outweigh the risks for many, many people with overweight or obesity, especially if they have other comorbid conditions related to metabolic or cardiovascular disorders.

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