u/klenow

I hate it when people downvote just because someone doesn't know something. The whistle is what made it famous (at least as far as I know, the whistle was kinda before my time) For informational purposes :

There was a guy back in the 70's who discovered what that little toy could do. It happened to come in a box of Cap'n Crunch, and he took on that nickname. (he wasn't the first to discover it, he just kinda made it popular. It's a really interesting story, I suggest looking it up!)

Turns out it works because the whistle made a tone at 2600Hz. By the time I came on the scene, those original whistles were long gone, but there were all kinds of plans on how to build a phone hacking device with simple electronics (aka a Blue Box). I made mine from stuff at Radio Shack. It was my first introduction to electronics. It wasn't even in a box.

There was other stuff you could do if you manipulated the tone more; the whole POTS (Plain Old Telephone) system was built around tone-based commands. If you knew the commands, you could do all kinds of stuff. Back then, there was sometimes a board on a BBS that was called "2600" where people shared tips and how-to's in textfiles.

I can make an obsolete phone system think that the call didn't go through so I can get free long distance so I can log into the interesting BBS's.

It's all about time, specifically you clearly choosing to spend more time with her.

Her being athletic, and being 11 gives you a great "in". Get involved in her sports. There are youth leagues that rely on parent volunteers to be coaches, assistant coaches, etc. They usually don't care if you don't have any experience with the game.

If you don't want to do that, enroll her in some kind of extra training. Take her to the training and spend that time watching. Talk to her about it on the way there and the way back. Make it a point that this is just a parent-child thing, the siblings don't come. Ever.

Either one of those give you a built in, routine time to spend with her. Yeah, it's a lot, but the only cure for this is to spend that attention on her. And that means time.

It is the inalienable right for each passage of cells to spontaneously self destruct with a bacillus infection if it so chooses.

It's in the Constitution.

Well, shit I was going to post something about a technique I found that strips the fabric softener residue. But point taken.

Do you report to the postdoc or to the PI?

Extra, related tip : when you make dinner, make twice as much as you need. Put the other half in the fridge and now you have lunch, too.

I can see my house! Or...at least I can see the trees that cover my house.

Oh, fuck that. I hung out with the people in the astrodome when I volunteered there. Yeah, some were homeless before, but most of them were just regular people who went through a tragedy and were trying like hell to recover.

He was unable to protect himself, so he was an easy target for other people who wanted more than what they had. For context, the Superdome in New Orleans after Katrina was a refugee center. There wasn't a lot of security, because the National Guard that got called in was overwhelmed with rescue efforts. It got violent in there; not as violent as the press reported at the time, but it certainly wasn't a sunshine and roses kind of place. Few refugee centers are.

They can both be assholes. It's not an either or situation.

Also, the only thing OP did (as far as we know) was vent online about it. Sure, they could have screeched by the guy and flipped him off nearly running a puppy over on the process, but that would just be conjecture.

I lived in Houston when Katrina hit New Orleans. Half that city wound up living in makeshift shelters in Houston. I was volunteering one night at one of the shelters in Houston (George R Brown Convention center) when the Superdome was evacuated. I was doing intake. We were getting people's names, finding out what medication they needed, see if they needed medical assistance etc. One guy came up with a bandaged arm. I asked him if a doctor had looked at it, and he said no, so I escorted him to the medical area, and he told me the story of how he hurt his arm.

When the water started rising, he went to the second floor of his home. When it rose further, he went into the attic. And the water kept coming. He had no way out of the attic. He had no tools, but he found a plank of wood, so he started attacking the inside of the roof with that as the water kept rising around him in the dark. He finally made a hole big enough to squirm through, and he tore up his arm getting out. He then spent that night on his roof, surrounded by water, waiting for rescue.

Then he went to the Superdome, which was another kind of hell. People saw he was injured, so they'd force him to give up his blankets, shoes, clothes, and meals. He hadn't had a proper meal in days. We swung by the kitch on the way to the clinic.

I've been in two major floods in my life, one before that and another after. I can't imagine being in the situation he was in. That had to be absolutely terrifying.

That you can break no law, yet still be an asshole.

Ok, what's your point? This post is tantamount to "I like fish, but not salmon. It's too fishy"

$3 mil, as long as it's just something I despise, and it's not something immoral.

I'm 55. I'll suck it up for 10 years, watch the clock like a hawk, and retire wealthy.

OK, I like this one. None of the crazy you get millions for doing something stupid...just the fantasy of a free $5k. I've got two, depending on the ruling.

Option 1 : Is a trip with my wife acceptable? Round trip tickets to New Zealand. Whatever is left over goes to food, lodging, etc.

Option 2 has 2 unrelated parts.

Part 1 : I am seriously upgrading my backpacking rig. Ultralight tent, pack, sleeping bag and pad, stove, great boots. That will cost about 2-3k

Part 2 : With the rest, I'm chartering a gulf stream fishing trip. Always wanted to do that. I can drive to the coast from where I live, so I just need the charter. I'll bring along a few friends, because fishing alone is not as fun as fishing with friends.

There are two reasons I'll read a paper, which means I read two different ways.

1) Looking for something specific. A certain interaction, an IC50, a method, etc : I'll look for the specific thing, and then kind of wind my way "out" from that to see how they support it. Say I'm looking for a method. I'll got to the methods section and see what they did. Nine times out of ten, it's not something that's relevant for me so I drop it then. If it is relevant, I'll look at their control data and see how well they characterized it...and go from there.

2) Reading it because it's an interesting or relevant topic. I read the abstract first. If it's a system I know well, I'll skip to the conclusion. If it's not, I'll read the intro, then the conclusion. Then I go through each figure and look at the data to see if it supports their conclusion. I'll skip from figure to methods, checking what the models are, etc. If I didn't read the intro by now, I'll go back and skim it. Then I'll read the results, then discussion. The point is to frame the paper (abstract, intro, conclusions) into what they are trying to say. Then go kick the tires (figures, results, methods) looking for the weak points in their model (because all models are wrong, you just need to understand how they're wrong). I wrap up with the discussion, which lets me know how they thing their stuff fits into the grand scheme. But I only do this once I've made a determination on what I think of their conclusions.

HOWEVER...I don't know if this is good for you. I've been wading through this stuff for 30 years, and this is only how I read papers in my field. This is literally my job, and I've spent a LOT of time getting good at it and learning the lingo.

If I come across an interesting astronomy paper (for example), I'll read that thing back to front, skipping over all the deep model stuff I don't understand, and just do abstract-intro-pretty pictures-conclusion. I know astronomy better than most people, and I've been a mega-nerd about it all my life, but my understanding of it is infinitesimal compared to my understanding of molecular biology because I have immersed myself that 10+ hours a day for the past 30+ years.

Hey! Stop it! That's my name, you're going to wear it out!

I'm 53. Fuck yes I'll do that.

I make drugs more potent.

At this point, I'd settle for one that isn't a pedophile and a rapist.

"Marginally competent" would be the stretch goal.

I don't know that this is true, but I always thought it came from statistics. When you run a comparison, you either disprove your null hypothesis, or you do nothing. You can't prove the null (can't prove a negative).

I've been in this industry long enough to see a few revolutions. In method, approach, technology, etc.

A friend of mine told me a few years ago, "You're not going to lose your job to AI. You're going to lose your job to the guy who knows how to use AI."

We're not going to have AI develop a drug all on its own anytime soon. (I've seen a few people try, it's not pretty). But, it's an incredibly useful tool. It is going to change things. It already has changed things. The people who use AI to model DMPK, to predict structures that can cause instability or side effect, to combine with proteomic data to find fingerprints, design devices, or just fucking manage their day are going to (and do) outperform the people who do those same things the "old fashioned" way.

It's another tool. A powerful tool, but still a tool.

20 miles a day on a level, even track with no gear to carry? Piece of cake. The question is how much of that bonus do I go for?

Bro, this is classic gay chicken and he is about to fukin OWN you.

Don't flinch, bro, don't be a pussy! You can take him!